Normal frontal perfusion in patients with frozen gait
Identifieur interne : 000564 ( France/Analysis ); précédent : 000563; suivant : 000565Normal frontal perfusion in patients with frozen gait
Auteurs : Nelly Fabre [France] ; Christine Brefel [France] ; Umberto Sabatini [Italie] ; Pierre Celsis [France] ; Jean Louis Montastruc [France] ; François Chollet [France] ; Rascol [France]Source :
- Movement Disorders [ 0885-3185 ] ; 1998-07.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte, Congélation.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Blocking, Blood Flow Velocity (physiology), Body movement, Brain Mapping, Comparative study, Dominance, Cerebral (physiology), Emission tomography, Exploration, Female, Freezing, Frontal Lobe (blood supply), Frontal Lobe (radionuclide imaging), Frontal lobe, Gait (physiology), Gait disorder, Hemodynamics, Humans, Idiopathic, Isolated gait ignition failure, Male, Muscle Rigidity (physiopathology), Muscle Rigidity (radionuclide imaging), Neurologic Examination, Neurons (physiology), Parkinson Disease (physiopathology), Parkinson Disease (radionuclide imaging), Parkinson disease, Parkinson's disease, Photon, Progressive supranuclear palsy, Regional Blood Flow (physiology), Regional blood flow, SPECT, Starting, Supranuclear Palsy, Progressive (physiopathology), Supranuclear Palsy, Progressive (radionuclide imaging), Tomography, Emission-Computed, Single-Photon, Xenon Radioisotopes (diagnostic use), rCBF.
- MESH :
- chemical , diagnostic use : Xenon Radioisotopes.
- blood supply : Frontal Lobe.
- physiology : Blood Flow Velocity, Dominance, Cerebral, Gait, Neurons, Regional Blood Flow.
- physiopathology : Muscle Rigidity, Parkinson Disease, Supranuclear Palsy, Progressive.
- radionuclide imaging : Frontal Lobe, Muscle Rigidity, Parkinson Disease, Supranuclear Palsy, Progressive.
- Aged, Aged, 80 and over, Brain Mapping, Female, Humans, Male, Neurologic Examination, Tomography, Emission-Computed, Single-Photon.
Abstract
We have studied the frontal perfusion in the resting condition of two groups of patients with frozen gait: 10 patients with the syndrome of “isolated gait ignition failure” (IGIF) and 8 patients with idiopathic Parkinson's disease (PD) and severe “off” freezing. These patients were compared with two other groups: one including 20 age‐matched volunteers as normal control subjects and the other one including 12 patients with progressive supranuclear palsy (PSP) as a positive control with expected frontal hypoperfusion. Frontal perfusion was assed using single photon emission computed tomography (SPECT) regional cerebral blood flow measurement with intravenous 133Xenon. A significant frontal hypoperfusion was only present in the PSP group but not in the three othrs. These results do not support the hypothesis that start hesitations and freezing when walking are related to a frontal lobe dysfunction. However, it is possible that frontal neuronla dysfunction occurs without measurable cerebral blood flow changes in the resting condition.
Url:
DOI: 10.1002/mds.870130412
Affiliations:
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ISTEX:6EA12089EAB32648A3EB89BE20774BC9351CE3F3Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1998-07">1998-07</date><biblScope unit="vol">13</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="677">677</biblScope><biblScope unit="page" to="683">683</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">6EA12089EAB32648A3EB89BE20774BC9351CE3F3</idno><idno type="DOI">10.1002/mds.870130412</idno><idno type="ArticleID">MDS870130412</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Blocking</term><term>Blood Flow Velocity (physiology)</term><term>Body movement</term><term>Brain Mapping</term><term>Comparative study</term><term>Dominance, Cerebral (physiology)</term><term>Emission tomography</term><term>Exploration</term><term>Female</term><term>Freezing</term><term>Frontal Lobe (blood supply)</term><term>Frontal Lobe (radionuclide imaging)</term><term>Frontal lobe</term><term>Gait (physiology)</term><term>Gait disorder</term><term>Hemodynamics</term><term>Humans</term><term>Idiopathic</term><term>Isolated gait ignition failure</term><term>Male</term><term>Muscle Rigidity (physiopathology)</term><term>Muscle Rigidity (radionuclide imaging)</term><term>Neurologic Examination</term><term>Neurons (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Photon</term><term>Progressive supranuclear palsy</term><term>Regional Blood Flow (physiology)</term><term>Regional blood flow</term><term>SPECT</term><term>Starting</term><term>Supranuclear Palsy, Progressive (physiopathology)</term><term>Supranuclear Palsy, Progressive (radionuclide imaging)</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Xenon Radioisotopes (diagnostic use)</term><term>rCBF</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Xenon Radioisotopes</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term><term>Blocage</term><term>Débit sanguin régional</term><term>Démarrage</term><term>Etude comparative</term><term>Exploration</term><term>Freezing</term><term>Hémodynamique</term><term>Idiopathique</term><term>Lobe frontal</term><term>Mouvement corporel</term><term>Parkinson maladie</term><term>Photon</term><term>Tomoscintigraphie</term><term>Trouble marche</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term><term>Congélation</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Frontal Lobe</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Flow Velocity</term><term>Dominance, Cerebral</term><term>Gait</term><term>Neurons</term><term>Regional Blood Flow</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Muscle Rigidity</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Frontal Lobe</term><term>Muscle Rigidity</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Neurologic Examination</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have studied the frontal perfusion in the resting condition of two groups of patients with frozen gait: 10 patients with the syndrome of “isolated gait ignition failure” (IGIF) and 8 patients with idiopathic Parkinson's disease (PD) and severe “off” freezing. These patients were compared with two other groups: one including 20 age‐matched volunteers as normal control subjects and the other one including 12 patients with progressive supranuclear palsy (PSP) as a positive control with expected frontal hypoperfusion. Frontal perfusion was assed using single photon emission computed tomography (SPECT) regional cerebral blood flow measurement with intravenous 133Xenon. A significant frontal hypoperfusion was only present in the PSP group but not in the three othrs. These results do not support the hypothesis that start hesitations and freezing when walking are related to a frontal lobe dysfunction. However, it is possible that frontal neuronla dysfunction occurs without measurable cerebral blood flow changes in the resting condition.</div></front></TEI><affiliations><list><country><li>France</li><li>Italie</li></country><settlement><li>Toulouse</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Fabre, Nelly" sort="Fabre, Nelly" uniqKey="Fabre N" first="Nelly" last="Fabre">Nelly Fabre</name></noRegion><name sortKey="Brefel, Christine" sort="Brefel, Christine" uniqKey="Brefel C" first="Christine" last="Brefel">Christine Brefel</name><name sortKey="Brefel, Christine" sort="Brefel, Christine" uniqKey="Brefel C" first="Christine" last="Brefel">Christine Brefel</name><name sortKey="Celsis, Pierre" sort="Celsis, Pierre" uniqKey="Celsis P" first="Pierre" last="Celsis">Pierre Celsis</name><name sortKey="Chollet, Francois" sort="Chollet, Francois" uniqKey="Chollet F" first="François" last="Chollet">François Chollet</name><name sortKey="Chollet, Francois" sort="Chollet, Francois" uniqKey="Chollet F" first="François" last="Chollet">François Chollet</name><name sortKey="Fabre, Nelly" sort="Fabre, Nelly" uniqKey="Fabre N" first="Nelly" last="Fabre">Nelly Fabre</name><name sortKey="Montastruc, Jean Louis" sort="Montastruc, Jean Louis" uniqKey="Montastruc J" first="Jean Louis" last="Montastruc">Jean Louis Montastruc</name><name sortKey="Rascol" sort="Rascol" uniqKey="Rascol" last="Rascol">Rascol</name><name sortKey="Rascol" sort="Rascol" uniqKey="Rascol" last="Rascol">Rascol</name></country><country name="Italie"><noRegion><name sortKey="Sabatini, Umberto" sort="Sabatini, Umberto" uniqKey="Sabatini U" first="Umberto" last="Sabatini">Umberto Sabatini</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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